Publications by authors named "K C Mathur"
Glioblastoma multiforme (GBM) is a World Health Organisation (WHO) grade IV glioma originating from astrocytes. It is the most common malignant primary tumour of the brain and central nervous system (CNS) and is associated with fast progression and violent local spread, with a median overall survival of approximately 15 months after diagnosis. Due to its late and varied presentation, it is often diagnosed only after it has grown considerably.
View Article and Find Full Text PDFCytomegalovirus (CMV) and Epstein-Barr virus (EBV) are important causes of viral esophagitis mainly in immunocompromised individuals. Both viruses lead to development of focal ulcerations in the esophagus. While there have been rare case reports of esophagitis in immunocompetent individuals, there has not been a single reported case of coinfection with both CMV and EBV in an immunocompetent individual and presenting with diffuse esophageal ulceration.
View Article and Find Full Text PDFHyperglycemia-Driven Insulin Signaling Defects Promote Parkinson's Disease-like Pathology in Mice.
ACS Pharmacol Transl Sci
December 2024
This study aims to determine the effect of chronic hyperglycemia, induced by a high-fat diet and STZ-induced diabetes, on the development of Parkinson's disease-like characteristics. Understanding this relationship is crucial in pharmacology, neurology, and diabetes, as it could potentially lead to developing new therapeutic strategies for Parkinson's disease. Our study employed a comprehensive approach to investigate the effect of hyperglycemia on Parkinson's disease-like characteristics.
View Article and Find Full Text PDFArticle Synopsis
- A 72-year-old woman with pre-existing health issues underwent an ERCP to remove bile duct stones but faced complications including abdominal pain and jaundice post-surgery.
- During the ERCP, she experienced a drop in oxygen saturation and arrhythmia, leading to a diagnosis of gas embolism confirmed by imaging, revealing air bubbles in her heart.
- Despite several emergency interventions, her condition worsened, and due to financial constraints, she was discharged against medical advice, highlighting the rarity and management difficulties of ERCP-related air embolism.
Article Synopsis
- Budd-Chiari syndrome (BCS) involves blockage of the hepatic veins and is often linked to a condition that causes increased blood clotting.
- Systemic amyloidosis is a disorder where misfolded proteins accumulate in the body, causing organ damage, and it typically leads to bleeding issues rather than clotting.
- The case of a 40-year-old man illustrates how AL amyloidosis can lead to BCS, showing the importance of recognizing its varied and non-specific symptoms for accurate diagnosis.