Publications by authors named "K C Mann"

Sexual minority women (e.g., lesbian, bisexual, pansexual) have increased risk of experiencing various mental health problems compared to sexual minority men and heterosexual individuals.

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The DMW is celebrating its 150th anniversary - and this period is precisely when endocrinology and diabetology evolved from the first experiments to molecular biology, genetic, and bioinformatics research. The DMW has always accompanied this process with numerous important publications, some of which are highlighted in this article.

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Article Synopsis
  • Transposable elements (TEs) make up half of the human genome and play crucial roles in regulating genes.
  • Some TEs are activated in normal cells but show different patterns of expression in cancer, which highlights their potential importance that hasn't been fully explored.
  • Tu et al. investigated the role of the TE POGK in triple-negative breast cancer (TNBC) and found that it works with TRIM28 to suppress the transcription of ribosomal genes, suggesting a tumor-suppressive function.
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Purpose Of Review: Worldwide, there is an increasing prevalence of hepatic diseases. The most common diseases include alcoholic-associated liver disease (ALD), metabolic dysfunction-associated fatty liver disease/ metabolic dysfunction-associated steatohepatitis (MAFLD/MASH) and viral hepatitis. While there are many important mediators of these diseases, there is increasing recognition of the importance of the inflammatory immune response in hepatic disease pathogenesis.

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The surge in multidrug-resistant bacteria against conventional antibiotics is a rapidly developing global health crisis necessitating novel infection management strategies. Host defence peptides (HDPs), also known as antimicrobial peptides (AMPs), offer a promising alternative to traditional antibiotics, but their practical translation is limited by their susceptibility to proteases and potential off-site cytotoxicity. In this paper, we investigate the feasibility of using gelatin emulsion gels (GELs), prepared using a water-in-oil (W/O) method, for the delivery of HDPs DJK-5 and IDR-1018 to improve their clinical utility.

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