Publications by authors named "K C Lodrup Carlsen"
Background: The gut microbiome plays a crucial role in the pathogenesis and progression of inflammatory bowel disease (IBD). Understanding the dynamics of the gut microbiome in relation to treatment can provide valuable insights into disease management and therapy strategies. The aim of this study is to investigate if diversity and composition of the gut microbiome correlate with time since treatment and disease activity during maintenance infliximab (IFX) therapy among children with IBD.
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- - The study investigates the potential link between human papillomavirus (HPV) infections during pregnancy and negative pregnancy outcomes, such as hypertensive disorders, gestational diabetes, and low birth weight newborns.
- - Data were collected from pregnant women in Norway and Sweden, examining urine samples for various HPV genotypes and analyzing their association with adverse outcomes using statistical models.
- - Results showed that 40% of participants had at least one HPV genotype, with 24% being high-risk types, indicating a notable prevalence, although the relationship between HPV and adverse outcomes is still being explored.
Age-related gut bacterial changes during infancy have been widely studied, but it remains still unknown how these changes are associated with immune cell composition. This study's aim was to explore if the temporal development of gut bacteria during infancy prospectively affects immune cell composition. Faecal bacteria and short-chain fatty acids were analysed from 67 PreventADALL study participants at four timepoints (birth to 12 months) using reduced metagenome sequencing and gas chromatography.
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- This study investigates the impact of nicotine exposure during pregnancy, particularly from smokeless tobacco (snus) and cigarettes, on infant lung function in a cohort of 1,163 infants measured at 3 months old.
- Results show that 10.3% of infants were exposed to nicotine in utero, with those exposed having a higher risk of lower lung function, indicated by an odds ratio of 1.63.
- The findings suggest both smoking and snus use during pregnancy can adversely affect infant respiratory health, and this effect is not significantly different between male and female infants.
Background: Largely unexplored, we investigated if lower lung function, impaired skin barrier function by transepidermal water loss (TEWL), eczema, and filaggrin (FLG) mutations in infancy were associated with asthma in early childhood.
Methods: From the factorially designed randomized controlled intervention study PreventADALL, we evaluated 1337/2394 children from all randomization groups with information on asthma at age 3 years, and at age 3 months either lung function, TEWL, eczema, and/or FLG mutations. Lower lung function was defined as the time to peak tidal expiratory flow to expiratory time (t /t ) <0.