Publications by authors named "K C Lewandowski"
Introduction: Ophthalmological manifestations (O-EIM) are one of the extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD), although their frequency and potential relationship with disease activity and treatment remain underestimated.
Aim: The aim of this screening questionnaire was to assess the number of EIM, including O-EIM, among patients with IBD.
Material And Methods: 436 patients with IBD and 102 patients without IBD were included in this single-centre retrospective study.
Summary: An oral contraceptive pill (OCP)-induced increase in total cortisol lead to reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis and insulin resistance (IR) in a patient with Addison's disease. We suggest that this might influence the choice of an OCP in such patients. A 20-year-old female was diagnosed with Addison's disease (cortisol: 44 nmol/L, adrenocorticotropic hormone (ACTH): >500 pg/mL) and started on hydrocortisone (HC).
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- Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) share similar neurobiological features, suggesting that BPD might be better classified as "traumatic personality stress disorder" (TPSD).
- The study explores how psychedelic-assisted therapy (PAT) could effectively treat both BPD and PTSD, emphasizing its role in stabilizing reward functions.
- Reclassifying BPD as TPSD may lead to more personalized treatment approaches, reduce stigma, and improve understanding and management of related psychological conditions.
Intranasal insulin increases brain glutathione (GSH) and enhances antioxidant capacity in healthy participants, but not in those with early psychotic disorders.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Article Synopsis
- * Twenty-one patients and 18 controls underwent pre- and post-insulin cognitive and magnetic resonance spectroscopy (MRS) assessments to measure changes in brain metabolites.
- * Results showed that while intranasal insulin increased glutathione levels and improved cognitive performance in healthy participants, it did not have the same effect in individuals with early psychotic disorders.
Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN) to help induce "dopamine homeostasis" in patients with PANDAS, especially those with known DNA-induced hypodopaminergia.
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