Acute severe hypocalcaemia after initiation of a selective RET-inhibitor in medullary thyroid cancer.

Medullary thyroid cancer (MTC) is a rare subtype of thyroid cancer originating from parafollicular C-cells of the thyroid. Tyrosine kinase inhibitors are used to treat patients with advanced MTC. Selpercatinib is a highly selective RET inhibitor used in the treatment of advanced RET-mutated MTC, having shown higher potency and fewer side effects compared to multikinase inhibitors in clinical trials.

Relating the molecular phenotype of ulcerative colitis to the clinical course.

The expanding portfolio of targeted therapies for ulcerative colitis (UC) suggests that a more precise approach to defining disease activity will aid clinical decision-making. This prospective study used genome-wide microarrays to characterize gene expression in biopsies from the most inflamed colon segments from patients with UC and analyzed associations between molecular changes and short-term outcomes while on standard-of-care treatment. We analyzed 141 biopsies-128 biopsies from 112 UC patients and 13 biopsies from eight inflammatory bowel disease unclassified (IBDU) patients.

Ultralow trap density FAPbBr perovskite films for efficient light-emitting diodes and amplified spontaneous emission.

Solution-processed metal halide perovskites are widely studied for their potential in high-efficiency light-emitting diodes, yet they are facing several challenges like insufficient brightness, short operational lifetimes, and reduced power conversion efficiency under practical operation conditions. Here, we develop an interfacial amidation reaction on sacrificial ZnO substrates to produce perovskite films with low trap density (1.2 × 10cm), and implement a device structure featuring a mono-molecular hole-injection layer and an all-inorganic bi-layered electron-injection layer.

A secure healthcare data transmission based on synchronization of fractional order chaotic systems.

The transmission of healthcare data plays a vital role in cities worldwide, facilitating access to patient's health information across healthcare systems and contributing to the enhancement of care services. Ensuring secure healthcare transmission requires that the transmitted data be reliable. However, verifying this reliability can potentially compromise patient privacy.