Publications by authors named "K C Igwe"
Article Synopsis
- The study investigates how Alzheimer's disease (AD) biomarkers relate to cognitive performance as measured by the NIHTB-CB in late middle-aged Hispanic individuals.
- Lower cortical thickness (CT) and the presence of infarcts were linked to poorer performance in reading recognition and overall cognition scores, while higher white matter hyperintensities (WMH) also negatively impacted processing speed.
- Interestingly, amyloid and tau levels, often associated with AD, showed no correlation with cognitive test performance, prompting further research to see if AD affects NIHTB-CB results over time.
Article Synopsis
- The study focuses on identifying early biomarkers for Alzheimer's disease in a diverse group of middle-aged individuals, using neuroimaging and cerebrospinal fluid markers.
- Researchers analyzed 76 cognitively healthy participants, comparing biomarkers like amyloid beta (Aβ)42 with brain connectivity and structure.
- Significant findings show that lower Aβ42 in Black Americans correlates with reduced brain connectivity and increased white matter hyperintensities, suggesting these may indicate higher Alzheimer's risk in this group.
Ingroup favoritism and intergroup discrimination can be mutually reinforcing during social interaction, threatening intergroup cooperation and the sustainability of societies. In two studies (N = 880), we investigated whether promoting prosocial outgroup altruism would weaken the ingroup favoritism cycle of influence. Using novel methods of human-agent interaction via a computer-mediated experimental platform, we introduced outgroup altruism by (i) nonadaptive artificial agents with preprogrammed outgroup altruistic behavior (Study 1; N = 400) and (ii) adaptive artificial agents whose altruistic behavior was informed by the prediction of a machine learning algorithm (Study 2; N = 480).
View Article and Find Full Text PDFBackground: Secondary prevention clinical trials for Alzheimer's disease (AD) target amyloid accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent other pathophysiological processes, such as small vessel cerebrovascular disease, account for participant performance on the primary cognitive outcomes in those trials. White matter hyperintensities are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) that reflect small vessel cerebrovascular disease. They are associated with cognitive functioning in older adults and with clinical presentation and course of AD, particularly when distributed in posterior brain regions.
View Article and Find Full Text PDFBackground And Purpose: Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal posterior cerebral artery (fPCA) correlate with brain arterial diameters across populations.
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