Osteomyelitis in infants and children. A review of 163 cases.

One hundred sixty-three cases of osteomyelitis in infants and children were seen at our hospital during the past 15 years. There were twice as many boys as girls. Staphylococcus aureus was the major etiologic agent, being identified in 61% of the cases.

Colicin types of Shigella sonnei in relation to antibiotic resistance.

Colicin typing of 436 strains of Shigella sonnei isolated in Dallas during a 10-year period was performed to determine whether resistance to ampicillin was associated with a single strain or was widespread among all S. sonnei types. One hundred ninety-three strains collected during a period of eight and one-half years when ampicillin resistance was 1.

Comparative efficacy of cephalexin and ampicillin for shigellosis and other types of acute diarrhea in infants and children.

Most ampicillin-resistant Shigella are susceptible to cephalexin. Randomized treatment with cephalexin or ampicillin was given to 154 infants and children with acute diarrhea. Rectal swab cultures revealed Shigella in 42%, Salmonella in 6%, enteropathogenic Escherichia coli in 2%, and no pathogen in 50%.

Ampicillin in Haemophilus influenzae meningitis. Clinicopharmacologic evaluation of intramuscular vs intravenous administration.

Sixty-two children with Haemophilus meningitis were treated with ampicillin sodium, 200 mg/kg/day for ten days. Thirty-one received the drug intravenously (IV) for ten days; the other 31 patients received ampicillin IV for five days (except for one test dose given intramuscularly [IM] on day 2) followed by IM administration of ampicillin the last five days. Ampicillin concentrations in cerebrospinal fluid (SCF) were higher one hour after IV administration, but at two and four hours, concentrations were greater after IM doses.