Publications by authors named "K C Divyansh Mishra"
Background: The objective of this study is to evaluate the risk of being diagnosed with an eating disorder among transgender and gender-diverse (TGD) individuals, specifically examining how this risk differs following gender-affirming medical therapy (GAMT).
Methods: The study utilizes electronic medical record (EMR) data from the TriNetX database. A total of 90,955 TGD individuals were identified in the TriNetX database.
ST elevation myocardial infarction as presenting feature of acute myeloid leukemia.
Med J Armed Forces India
December 2024
A 35-year-old male patient with acute myeloid leukemia (AML), with hyperleukocytosis, presented with acute myocardial infarction. The individual had acute onset chest pain and reached the hospital within the window period. His electrocardiogram (ECG) revealed ST elevated myocardial infarction (STEMI), ST elevated myocardial infarction, and thrombolysis was performed.
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- The high altitude environment can harm the gastrointestinal tract, causing discomfort and injury to the intestinal barrier.
- Sodium butyrate, a gut metabolite, has shown potential as a treatment that can reduce inflammation and restore the integrity of intestinal cells.
- In laboratory studies, sodium butyrate effectively lowered inflammatory markers and improved cell barrier function, suggesting it may be a key factor in managing gut health under hypoxic conditions.
In oncology drug development, overall response rate (ORR) is commonly used as an early endpoint to assess the clinical benefits of new interventions; however, ORR benefit may not always translate into a long-term clinical benefit such as overall survival (OS). Most of the work on developing endpoints based on tumor growth dynamics relies on empirical validation, leading to a lack of generalizability of the endpoints across indications and therapeutic modalities. Additionally, many of these metrics are model-based and do not use data from all the patients.
View Article and Find Full Text PDFBackground: The subarachnoid block is the predominant and relatively safe approach during lower limb orthopaedic operations. When used as an additive to intrathecal local anaesthetic, both fentanyl and dexmedetomidine can extend the duration of sensory and motor blockade and improve postoperative analgesia.
Objectives: The objective of this study is to assess and compare the efficacy of sequential administration of fentanyl and dexmedetomidine alongside 0.