Gehyra Geckos Prioritize Warm Over Humid Environments.

Maintaining stable hydric and thermal states are dual challenges for reptiles that inhabit terrestrial environments with variable conditions across time and space. Under some conditions, reptiles face a conundrum where both physiological parameters cannot be simultaneously maintained at preferred levels by behavioral or physiological means. Prioritization of behavioral regulation of hydric or thermal state, and at which point this prioritization changes, was tested for nine species of congeneric tropical geckos by assessing their use of microhabitats with distinct thermal and hydric conditions in a controlled environment.

Rationalizing mAb Candidate Screening Using a Single Holistic Developability Parameter.

A framework for the rational selection of a minimal suite of nondegenerate developability assays (DAs) that maximize insight into candidate developability or storage stability is lacking. To address this, we subjected nine formulation:mAbs to 12 mechanistically distinct DAs together with measurement of their accelerated and long-term storage stability. We show that it is possible to identify a reduced set of key variables from this suite of DAs by using orthogonal statistical methods.

Adaptation of ACMG/AMP guidelines for clinical classification of variants in Pulmonary Arterial Hypertension resolves variants of unclear pathogenicity in ClinVar.

Purpose: Pulmonary arterial hypertension (PAH) is a rare disease that can be caused by pathogenic variants, most frequently in the bone morphogenetic protein receptor type 2 ( ) gene. We formed a ClinGen variant curation expert panel to devise guidelines for the clinical interpretation of variants identified in PAH patients.

Methods: The general ACMG/AMP variant classification criteria were refined for PAH and adapted to following ClinGen procedures.

The Effect of Intervention Preference Matching on Outcomes and Engagement in a Post-cessation Weight Management Trial.

Purpose: This study examined the effect of intervention treatment preference in a post-smoking cessation weight management trial.

Design & Setting: Participants were randomized to a weight management intervention (Stability, Loss, or Bibliotherapy); all participants received a standard smoking cessation program. Adults aged 18+ were recruited from Memphis, TN, and nationally.

Church Leaders' Health Behaviors and Program Implementation in the Faith, Activity, and Nutrition Program.

Objectives: Church leaders are important to the success of faith-based health promotion interventions through the role modeling of health behaviors. However, clergy may be at a higher risk of chronic disease than their congregants and their health is understudied. This study examined church leaders' health-related behaviors, differences in health behaviors by sociodemographic characteristics, and associations between health behaviors and church-level implementation of an ecological intervention.