Publications by authors named "K C Chavin"
Article Synopsis
- This study examines kidney retransplantation (re-KT) outcomes specifically comparing HIV-positive (HIV+) and HIV-negative (HIV-) patients from 2014 to 2022.
- The research shows that HIV+ recipients face higher risks of graft loss due to factors like being more likely to be Black, experiencing delayed graft function, and having significant HLA mismatches.
- The findings indicate a need for better organ matching and strategies to improve re-KT success in HIV+ patients, as they exhibited significantly lower graft survival rates overall.
Background And Aims: Effective approaches for prevention of hepatocellular carcinoma (HCC) will have a significant impact on HCC-related mortality. There are strong preclinical data and rationale to support targeting epidermal growth factor receptor (EGFR) for HCC chemoprevention. Small molecule inhibitors of EGFR have been Food and Drug Administration-approved for cancer therapy, which provides an opportunity to repurpose one of these drugs for chemoprevention of HCC.
View Article and Find Full Text PDFHypogonadism is understudied in men requiring solid organ transplants, particularly among lung transplant recipients. Improvement in serum testosterone levels has been reported in kidney and liver transplantation. Using the TriNetX Research Network, we performed a retrospective cohort study to evaluate the incidence of peri-transplant hypogonadism and the natural course of serum testosterone following successful lung transplantation.
View Article and Find Full Text PDFArticle Synopsis
- Donor-derived cell-free DNA (dd-cfDNA) is an innovative noninvasive biomarker being studied for its ability to detect kidney allograft injuries, such as rejection.
- In a study involving 2,882 kidney transplant recipients, high levels of dd-cfDNA were strongly linked to various types of allograft rejection, and it significantly improved prediction models beyond what's typically used in patient monitoring.
- The study, which included diverse cohorts, reinforced that measuring dd-cfDNA could enhance the detection of even subtle rejection in stable patients, providing valuable insights for better transplant management.
Importance: A new liver allocation policy was implemented by United Network for Organ Sharing (UNOS) in February 2020 with the stated intent of improving access to liver transplant (LT). There are growing concerns nationally regarding the implications this new system may have on LT costs, as well as access to a chance for LT, which have not been captured at a multicenter level.
Objective: To characterize LT volume and cost changes across the US and within specific center groups and demographics after the policy implementation.