Publications by authors named "K Byth"
Article Synopsis
- The ROLEX-DUO study is a randomized controlled trial aimed at understanding if high-intensity resistance and impact exercise combined with romosozumab can improve bone density and muscle outcomes in postmenopausal women with osteoporosis/osteopenia.
- The trial involves 102 participants who will be divided into three groups: one receiving romosozumab with supervised high-intensity exercise, another receiving romosozumab with low-intensity exercise, and a third group getting a placebo with low-intensity exercise.
- Key outcomes to be measured include changes in lumbar spine bone mineral density and performance on a sit-to-stand test, along with various secondary health indicators related to bone health and quality of life over an 8-month period
Article Synopsis
- Cardiac amyloidosis (CA) is often overlooked as a cause of heart failure and involves left atrial (LA) myopathy, which worsens prognosis and is linked to atrial fibrillation (AF).
- This study evaluated the echocardiographic features of LA myopathy in patients with transthyretin (ATTR) and light-chain (AL) CA compared to those with hypertensive heart disease (HHT).
- Findings showed that both ATTR and AL patients had significant heart function impairments, particularly in LA-MD, which was associated with a higher risk of mortality, highlighting the importance of LA evaluations in CA prognosis.
Background: Single-lead electrocardiogram (ECG) devices may allow detection and diagnosis of cardiac rhythms. However, data on their accuracy for detecting cardiac arrhythmias beyond atrial fibrillation are limited. We aimed to determine the accuracy of the AliveCor KardiaMobile (AC) (AliveCor Inc, Mountain View, CA, USA) for the diagnosis of arrhythmias against gold standard cardiac electrophysiology study (EPS).
View Article and Find Full Text PDFLevothyroxine may not adequately prepare hypothyroid women for controlled ovarian hyperstimulation.
Aust N Z J Obstet Gynaecol
June 2024
Background: Thyroid axis dysregulation during controlled ovarian hyperstimulation (COH) is more pronounced in hypothyroid-treated women. Whether or not this leads to compromised thyroid hormone levels within the ovarian follicular fluid is not known.
Aims: To determine whether ovarian follicular thyroid hormone levels are compromised in adequately replaced hypothyroid women undergoing controlled ovarian hyperstimulation (COH), and/or influence cycle/pregnancy outcomes.
Article Synopsis
- Anthracycline chemotherapy for breast cancer can lead to heart issues, and recent guidelines suggest using Global Longitudinal Systolic Strain (GLS) to detect early signs of cardiac dysfunction before more severe symptoms develop.
- A study involving 114 HER2 negative breast cancer patients assessed subclinical cardiac dysfunction through echocardiograms at three stages during treatment, revealing that 38% experienced significant reductions in GLS over 12 months, even though no patients met the criteria for more advanced heart failure.
- The research suggests a method for identifying at-risk patients by combining the percentage reduction in GLS and absolute GLS values, which could help in adjusting care strategies for those with high baseline GLS levels.