Publications by authors named "K Butterworth"
Background: Radiation-induced cardiotoxicity poses a significant challenge in lung cancer management because of the close anatomical proximity of the heart to the lungs, compounded by a high prevalence of cardiovascular risk factors among patients.
Objectives: The aim of this study was to assess the predictive value of routinely available clinical and imaging-based cardiac parameters in identifying "high risk" patients for major adverse cardiac events (MACE) and mortality following radiation therapy (RT).
Methods: The medical records of patients who underwent definitive RT for non-small cell lung cancer using modern planning techniques at a single center between 2015 and 2020 were retrospectively reviewed.
Background And Purpose: Radiomics analysis extracts quantitative data (features) from medical images. These features could potentially reflect biological characteristics and act as imaging biomarkers within precision medicine. However, there is a lack of cross-comparison and validation of radiomics outputs which is paramount for clinical implementation.
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- Radiotherapy (RT) is crucial for treating non-small cell lung cancer (NSCLC), but local recurrence remains a challenge, particularly in late-stage patients with PTEN loss contributing to increased radio-resistance.
- This study investigated the effectiveness of combining RT with the ATR inhibitor Ceralasertib in PTEN-depleted NSCLC cells, using both in vitro and in vivo models, which showed significant tumor growth inhibition and delayed DNA repair.
- The results indicated that this combination selectively sensitizes PTEN-depleted NSCLC without causing early inflammatory responses typically associated with radiation pneumonitis, supporting further investigation of ATR inhibition alongside RT for patients with PTEN mutations.
Background: Preclinical models of radiotherapy (RT) response are vital for the continued success and evolution of RT in the treatment of cancer. The irradiation of tissues in mouse models necessitates high levels of precision and accuracy to recapitulate clinical exposures and limit adverse effects on animal welfare. This requirement has been met by technological advances in preclinical RT platforms established over the past decade.
View Article and Find Full Text PDFBackground And Purpose: Radiation induced cardiotoxicity (RICT) is as an important sequela of radiotherapy to the thorax for patients. In this study, we aim to investigate the dose and fractionation response of RICT. We propose global longitudinal strain (GLS) as an early indicator of RICT and investigate myocardial deformation following irradiation.
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