COMPARATIVE ANALYSIS OF EFFICIENCY OF URSODEOXYCHOLIC ACID AND COMBINATION OF VITAMIN E AND VITAMIN C IN TREATMENT OF NON-DIABETIC NONALCOHOLIC STEATOHEPATITIS.

Nonalcoholic steatohepatitis (NASH) is a frequent liver disease that can progress to cirrhosis and for which effective therapy is still lacking. Despitean important role of oxidative stress in the pathogenesis of NASH, antioxidant approaches have not been investigatedsufficiently. The aim of the study was to compare the efficacy of ursodeoxycholic acid (UDCA) versus vitamin E plus vitamin C in non-diabetic patients with nonalcoholic steatohepatitis.

[Breast cancer immunohistochemical features in different age groups].

We investigated 52 incidents of the breast cancer to determine their immunological profile in the different age groups. Breast tissue-specific and at the same time oncologically important immunohistochemical markers: estrogen- and progesterone receptors (ER, PR), oncoprotein HER-2/neu, protein PS2, markers of angiogenesis CD31 and mitotic activity Ki-67 were investigated. Patients were divided into 3 group: I - patients under 45 years (23), II - from 46 to 55 (14), III - 56 year and older (15).

[Immunohistochemical investigation of steroid hormones (ER, PR) in breast cancer].

Immunohistochemical investigations were performed in 22 cases of breast cancer. The objective of this study was to assess the presence and distribution of ER and PR in the cancer tissue. We found that expression of the ER and PR in the cancer tissue is variable, which depends on cancer histogenesis (lobular, ductal), histological form, differentiation grade, and stage of its development.