Publications by authors named "K Burg"

Long noncoding RNAs (lncRNAs) are transcribed elements increasingly recognized for their roles in regulating gene expression. Thus far, however, we have little understanding of how lncRNAs contribute to evolution and adaptation. Here, we show that a conserved lncRNA, , is an important color patterning gene in the buckeye butterfly .

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Article Synopsis
  • Oncology is shifting towards genome-driven practices, but most cancer diagnostics still rely on traditional microscopy methods, creating delays in using new genomic biomarkers for patient treatment.* -
  • Whole-genome sequencing (WGS) can improve diagnostics by detecting numerous genomic changes in one cost-effective test, and it has been shown to be feasible and valid in a clinical setting, with results provided in about 11 workdays.* -
  • Successful WGS implementation, such as at the Netherlands Cancer Institute, requires a detailed protocol addressing sample handling and integration into clinical workflows to overcome challenges faced by pathology labs using conventional sample methods.*
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Discovering novel ice-binding proteins (IBPs) is important for understanding the evolution of IBPs but it is difficult to determine where resources should be directed in the search for novel IBPs. For this reason, we developed a simple bioinformatic approach for aiding in the determination of where to direct efforts in the search for IBPs. First, BLAST is used to obtain a candidate list of putative IBPs.

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Allochronic speciation, where reproductive isolation between populations of a species is facilitated by a difference in reproductive timing, depends on abiotic factors such as seasonality and biotic factors such as diapause intensity. These factors are strongly influenced by latitudinal trends in climate, so we hypothesized that there is a relationship between latitude and divergence among populations separated by life history timing. Hyphantria cunea (the fall webworm), a lepidopteran defoliator with red and black colour morphs, is hypothesized to be experiencing an incipient allochronic speciation.

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Phenotypic plasticity enables rapid responses to environmental change, and could facilitate range shifts in response to climate change. What drives the evolution of plasticity at range edges, and the capacity of range-edge individuals to be plastic, remain unclear. Here, we propose that accurately predicting when plasticity itself evolves or mediates adaptive evolution at expanding range edges requires integrating knowledge on the demography and evolution of edge populations.

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