Publications by authors named "K Budd"
Article Synopsis
- Echinoderms play vital roles in coral reef ecosystems as detritivores and herbivores but experience boom and bust cycles due to food and predation factors, necessitating pathogen surveillance for ecological understanding.
- The study conducted viral surveillance on two common reef echinoderms using metagenomics during a mass mortality event and compared normal specimens from different locations to identify viral associations.
- Findings indicated that one echinoderm lacked common viral infections, while the other showed similarities to viruses found in other species, suggesting methods used may affect viral detection and highlighting the need for further investigation into the role of viruses in mass mortalities.
Background: Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant-type hemispheric glioma (IHG) but also in other pHGG and are associated with devastating morbidity and mortality.
Methods: To identify new treatment options, we established and characterized two novel orthotopic mouse models harboring distinct MET fusions.
Habitat loss and fragmentation are leading contributors to the endangered status of species. In 2006, the Nakai Plateau contained the largest known Asian elephant () population in the Lao People's Democratic Republic (Lao PDR), and the population was among those with the highest genetic diversity reported for Asian elephants. In 2008, completion of the Nam Theun 2 hydroelectric dam inundated much of the Plateau, resulting in the loss of 40% of elephant habitat.
View Article and Find Full Text PDFRecurrent, clonal somatic mutations in histone H3 are molecular hallmarks that distinguish the genetic mechanisms underlying pediatric and adult high-grade glioma (HGG), define biological subgroups of diffuse glioma, and highlight connections between cancer, development, and epigenetics. These oncogenic mutations in histones, now termed "oncohistones", were discovered through genome-wide sequencing of pediatric diffuse high-grade glioma. Up to 80% of diffuse midline glioma (DMG), including diffuse intrinsic pontine glioma (DIPG) and diffuse glioma arising in other midline structures including thalamus or spinal cord, contain histone H3 lysine 27 to methionine (K27M) mutations or, rarely, other alterations that result in a depletion of H3K27me3 similar to that induced by H3 K27M.
View Article and Find Full Text PDFCollege drinkers commonly report blacking out (i.e., alcohol-induced amnesia), and those who drink with the intention to blackout are at risk for harmful consequences.
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