Publications by authors named "K Brummond"
We report a stereo-differentiating dynamic kinetic asymmetric Rh(I)-catalyzed Pauson-Khand reaction, which provides access to an array of thapsigargin stereoisomers. Using catalyst-control, a consistent stereochemical outcome is achieved at C2─for both matched and mismatched cases─regardless of the allene-yne C8 stereochemistry. The stereochemical configuration for all stereoisomers was assigned by comparing experimental vibrational circular dichroism (VCD) and C NMR to DFT-computed spectra.
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- * This study identified key parameters, including ligand properties and solvent effects, that predict the yield and enantioselectivity of the PKR, particularly using 1,6-enynes with 2,2-disubstituted alkenes to produce chiral cyclopentenones.
- * Findings showed strong correlations between experimental outcomes and factors like ligand structure, solvent dipole moments, and the steric demand of alkyne