Direct acting antivirals eradicate HCV from the liver quickly in people with HIV but do not fully reverse immune activation.

Background: Hepatitis C virus (HCV) infects nearly one-fourth of people with HIV (PWH). The role of direct-acting antivirals (DAAs) on immune activation in PWH and HCV is poorly understood.

Methods: We quantified plasma HCV RNA and CXCL10 in persons with HCV mono- versus HIV/HCV co-infection receiving Sofosbuvir-Velpatasvir.

Reducing the carbon footprint of radiology through automatic workstation shutdown protocols.

Aim: Climate change poses a major threat to human health, with significant contributions from healthcare systems, with the UK National Health Service (NHS) accounting for 4% of national CO emissions. Radiology departments, with high energy consumption from heating, ventilation, cooling (HVAC), and scanners, also contribute significantly. Workstations, though less power-intensive than scanners, are numerous and offer an avenue for emission reduction potential.

Elevated nuclear TDP-43 induces constitutive exon skipping.

Background: Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate in vitro and in vivo model systems.

Methods: We analyzed RNA-seq datasets from mouse and human neurons overexpressing TDP-43 to explore species specific splicing patterns.

Impact of billing reforms on academic hospitalist physician and advanced practice provider collaboration: A qualitative study.

Background: Medicare previously announced plans for new billing reforms for inpatient visits that are shared by physicians and advanced practice providers (APPs) whereby the clinician spending the most time on the patient visit would bill for the visit.

Objective: To understand how inpatient hospital medicine teams utilize APPs in patient care and how the proposed billing policies might impact future APP utilization.

Design, Setting And Participants: We conducted focus groups with hospitalist physicians, APPs, and other leaders from 21 academic hospitals across the United States.