Publications by authors named "K Borka"
Article Synopsis
- - The study focuses on pancreatic neuroendocrine neoplasms (PanNET), which are becoming increasingly common and have unpredictable outcomes, and looks into using microRNAs (miRNAs) as potential markers to differentiate between grade 1 (G1) and grade 2 (G2) tumors.
- - Researchers analyzed 33 tumor samples (17 G1 and 16 G2) and found that specific miRNAs were significantly less active in G2 tumors, confirming their potential role in diagnosis via advanced sequencing and real-time PCR methods.
- - Using machine learning, the study identified a combination of miRNAs that effectively differentiated between G1 and G2 PanNETs, achieving an 83.33% sensitivity and 87.5
Prostate cancer stands as the most prevalent malignant tumor among men; with its incidence increasing with advancing age. The spectrum of patient care options for this disease is broad, encompassing approaches such as "active surveillance," definitive radiation therapy, robot-assisted surgery, among others. These diverse modalities afford opportunities for cure or successful management in the majority of cases.
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- * Research showed that smokers, both with and without CP, have higher sweat chloride levels and lower CFTR expression, indicating impaired CFTR activity due to smoking.
- * Exposure to cigarette smoke and associated heavy metals like cadmium harms pancreatic function by reducing fluid and bicarbonate secretion and increasing intracellular calcium and ATP depletion.
Article Synopsis
- Cowden syndrome (CS) is a rare genetic disorder linked to mutations in the PTEN tumor suppressor gene, increasing the risk of various tumors, including thyroid and breast cancers.
- A case study highlights a 46-year-old man with a history of testicular seminoma and thyroid cancer who was diagnosed with CS through genetic testing that confirmed a PTEN mutation.
- This patient also exhibited multiple pulmonary carcinoid tumors, marking him as the first reported case of CS linked to these specific tumors, suggesting CS may predispose individuals to multifocal pulmonary lesions.
In congenital hyperinsulinemic hypoglycemia - the most common cause of persistent hypoglycemia in infancy - a focal lesion can be identified in 50% of the cases. With appropriate medical care based upon early diagnosis, these patients can be cured by the resection of the lesion rendering unnecessary long time medical care, and avoiding serious brain damage from recurrent hypoglycemic episodes. Genetic testing and 18F-fluoro-dihydroxyphenylalanine PET/CT imaging are essential for determining the best possible treatment.
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