Publications by authors named "K Bordji"
To treat colorectal liver metastases, intra-arterial chemotherapies may complete therapeutic arsenal. Drugs using intra-arterially are very heterogeneous. The aim of this study was to select the most efficient drug on a panel of colorectal cancer (CRC) cell lines (Caco-2, HCT 116, HT 29, SW 48, SW 480, SW 620) exposed for 30 min to 12 cytotoxic agents (doxorubicin, epirubicin, idarubicin, 5-FU, raltitrexed, gemcitabine, cisplatin, oxaliplatin, mitomycin C, irinotecan, streptozocin, paclitaxel) at different concentrations.
View Article and Find Full Text PDFApproaches able to counteract, at least temporarily, hypoxia, a well-known factor of resistance to treatment in solid tumors are highly desirable. Herein, we report the use of nanosized zeolite crystals as hyperoxic/hypercapnic gas carriers for glioblastoma. First, the non-toxic profile of nanosized zeolite crystals in living animals (mice, rats and non-human primates) and in various cell types is presented.
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- Tumor hypoxia reduces the effectiveness of radiation therapy, highlighted by the concept of oxygen enhancement ratio (OER), which is influenced by factors like pO and linear energy transfer (LET).
- Glioblastoma (GB) shows resistance to low-LET radiation (like X-rays) due to its hypoxic environment, prompting research into whether high-LET radiation, particularly carbon ion radiotherapy (CIRT), can counteract this resistance.
- The study evaluated the effects of CIRT on two human GB cell lines under varying LET conditions and found that while CIRT is generally more effective than X-rays, the presence of hypoxia continues to limit its effectiveness, with potential variations based on ERK activation and EPO signaling.
Purpose: Hypoxia in gliomas is associated with tumor resistance to radio- and chemotherapy. However, positron emission tomography (PET) imaging of hypoxia remains challenging, and the validation of biological markers is, therefore, of great importance. We investigated the relationship between uptake of the PET hypoxia tracer [18F]-FMISO and other markers of hypoxia and angiogenesis and with patient survival.
View Article and Find Full Text PDFGlioblastoma multiforme (GBM) is the deadliest form of primary brain cancer. Several reports have indicated aberrant levels of βIII-tubulin (βIII-t) in human GBM. βIII-t overexpression was linked to increasing malignancy in glial tumors and described to determine the onset of resistance to chemotherapy.
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