Publications by authors named "K Boldt"
The high performance of generative artificial intelligence (AI) and large language models (LLM) in examination contexts has triggered an intense debate about their applications, effects and risks. What legal aspects need to be considered when using LLM in teaching and assessment? What possibilities do language models offer? Statutes and laws are used to assess the use of LLM: - University statutes, state higher education laws, licensing regulations for doctors - Copyright Act (UrhG) - General Data Protection Regulation (DGPR) - AI Regulation (EU AI Act) LLM and AI offer opportunities but require clear university frameworks. These should define legitimate uses and areas where use is prohibited.
View Article and Find Full Text PDFPolarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Conditional knockout of Dlg1 in mouse kidney causes ciliary elongation and cystogenesis, and cell-based proximity labeling proteomics and fluorescence microscopy show alterations in the ciliary proteome upon loss of DLG1.
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- - Protein-protein interaction experiments often produce false positives, but the new WeSA (Weighted SocioAffinity) metric helps to differentiate genuine interactions from noise by analyzing large datasets like IntAct and BioGRID.
- - WeSA has been shown to improve accuracy in determining interaction confidence, achieving high scores in ROC analysis with results indicating high true positive rates and precision rates (AUC = 0.93, TPR = 0.84, FPR = 0.11, Precision = 0.98).
- - The WeSA web server is user-friendly and allows researchers to submit their own data or explore existing human protein interaction information, with results displayed in tables and network visualizations to easily identify and remove false positives
Bronchiectasis is a pathological dilatation of the bronchi in the respiratory airways associated with environmental or genetic causes (e.g., cystic fibrosis, primary ciliary dyskinesia, and primary immunodeficiency disorders), but most cases remain idiopathic.
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- CRB1 and CRB2 are crucial genes associated with retinitis pigmentosa and Leber congenital amaurosis, diseases known for their varied clinical presentations.
- In experiments, CRB1 and CRB2 were found to co-localize in both human retinas and retinal organoids, indicating a significant interaction between the two proteins.
- Mutations in the extracellular domain of CRB1 or CRB2 only mildly affected their interaction, suggesting that their relationship is stable in the retinal context.