Publications by authors named "K Bogunia-Kubik"
Background: Multiple myeloma (MM) is a hematological malignancy characterized by the presence of abnormal plasma cells. It is associated with anemia, bone lesions and renal dysfunction. Immunomodulatory drugs (IMiDs) are commonly used in MM treatment.
View Article and Find Full Text PDFVitamin D levels have been related to the severity and progression of various autoimmune disorders. In this study, we aimed to investigate the impact of genetic variability in the vitamin D receptor (VDR) gene on disease susceptibility and progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF) inhibitors. The study comprises 121 RA patients subjected to anti-TNF therapy genotyped for four VDR polymorphic variants: rs1544410 (I), rs2228570 (I), rs731236 (I), and rs7975232 (I).
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- Natural killer (NK) cells can detect and destroy malignant cells using specific receptors, and the study investigates how certain genetic variations in these receptors impact relapse and graft-versus-host disease (GVHD) after stem cell transplantation.
- Researchers analyzed 1,638 genetic variations in 21 non-KIR NK cell receptor genes among 1,491 donors from multiple countries to assess their effects on relapse and GVHD, identifying eleven relevant polymorphisms.
- Although some genetic variations showed potential links to NK cell activity in vitro, the overall findings did not demonstrate strong effects of these non-KIR NK cell receptors on HSCT outcomes, as associations were not confirmed in the replication cohort.
Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.
Hum Immunol
November 2024
Despite new treatment strategies, graft-versus-host disease (GvHD) remains a formidable complication after allogeneic hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the impact of polymorphisms and expression of MICA and NKG2D receptor on the development of GvHD in allogeneic HSCT recipients. Soluble MICA (sMICA) concentration was measured in serum collected 30 days after transplantation and the genetic variability of MICA and NKG2D genes was evaluated.
View Article and Find Full Text PDFAging is an exceptionally complex process that depends on genetic, environmental, and lifestyle factors. Previous studies within the International HLA and Immunogenetics Workshop (IHIWS) component "Immunogenetics of Ageing" showed that longevity is associated with positive selection of HLA-DRB1*11- and DRB1*16-associated haplotypes, shown to be protective against diseases. Within the 18th IHIWS, we aimed to investigate the relevance of telomere length for successful aging and its association with classical HLAs.
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