Publications by authors named "K Boberg"
Article Synopsis
- People with primary sclerosing cholangitis (PSC) are at a significant risk of developing biliary tract cancer (BTC), and this study used whole-exome sequencing to analyze the genetic changes in BTC associated with PSC.
- The researchers identified 53 candidate cancer genes, including some that had not been previously linked to BTC, while also recognizing genes known to be involved in other cancers.
- Their findings reveal specific and common genetic alterations that could improve understanding of BTC development in PSC, paving the way for personalized treatment strategies.
Article Synopsis
- Cutaneous squamous cell carcinoma (cSCC) can lead to multiple tumors and is dangerous for both immunocompetent and immunosuppressed patients, including organ transplant recipients.
- This study analyzed data from nearly 48,000 cSCC patients in Norway to compare the rates of second cSCC, metastasis, and mortality between those who received organ transplants and those who didn't.
- Findings revealed that organ transplant recipients had significantly higher rates of second cSCC (4.3 times more) and metastasis (1.5 times more), with a small percentage of deaths from cSCC, especially in the transplant group.
Reply: The mucosal gut signature in primary sclerosing cholangitis before and after liver transplantation. Is the dysbiosis index really predictive for the recurrence of PSC?
Hepatology
June 2023
What is this summary about? This is a plain language summary of the STEP TEENS research study, which was originally published in the . As more teenagers are living with obesity than ever before, researchers are searching for new treatments. This was the first study looking at how well the medicine semaglutide works as a treatment for obesity in teenagers.
View Article and Find Full Text PDFBackground And Aims: Several characteristic features of the fecal microbiota have been described in primary sclerosing cholangitis (PSC), whereas data on mucosal microbiota are less consistent. We aimed to use a large colonoscopy cohort to investigate key knowledge gaps, including the role of gut microbiota in PSC with inflammatory bowel disease (IBD), the effect of liver transplantation (LT), and whether recurrent PSC (rPSC) may be used to define consistent microbiota features in PSC irrespective of LT.
Approach And Results: We included 84 PSC and 51 liver transplanted PSC patients (PSC-LT) and 40 healthy controls (HCs) and performed sequencing of the 16S ribosomal RNA gene (V3-V4) from ileocolonic biopsies.