Fatigue After Stroke Educational Recovery Program: A Prospective, Phase III, Randomized Controlled Trial.

Background: Poststroke fatigue affects ≈50% of patients with stroke, causing significant personal, societal, and economic burden. In the FASTER (Fatigue After Stroke Educational Recovery) study, we assessed a group-based educational intervention for poststroke fatigue.

Methods And Results: Two hundred patients with clinically significant fatigue were included and randomized to either a general stroke education control or fatigue management group (FMG) intervention and assessed at baseline, 6 weeks, and 3 months.

Multilevel Mediators on the Associations of Neighborhood Social Environmental Factors and Severity of Metabolic Syndrome: The Jackson Heart Study.

Background: Neighborhood characteristics serve as risk factors for metabolic syndrome (MetS). However, the intermediary factors linking this relationship remain understudied. Thus, we investigated the sex-specific mediating role of C-reactive protein, physical activity (PA), and perceived stress in the associations of perceived neighborhood social environment (PNSE) with MetS severity among Black adults.

Defining the transition from new to normal: a qualitative investigation of the clinical change process.

Background: Understanding how and when a new evidence-based clinical intervention becomes standard practice is crucial to ensure that healthcare is delivered in alignment with the most up-to-date knowledge. However, rigorous methods are needed to determine when a new clinical practice becomes normalized to the standard of care. To address this gap, this study qualitatively explores how, when, and why a clinical practice change becomes normalized within healthcare organizations.

Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate.

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million people are infected by this parasite of which 20-30% will progress to develop Chronic Chagasic Cardiomyopathy (CCC). Despite its high disease burden, no clinically approved vaccine exists for the prevention or treatment of CCC.

A Tale of Two Tails: Tail Ordering of Stoichiometric 1:1 DTAB:SDS Pairs Adsorbed at the Oil-Water Interface.

Cationic:anionic surfactant mixtures adsorbed at an oil-water interface stabilize foams in the presence of oil, making them essential to the oil, gas, and firefighting industries. The oil tolerance of foams stabilized by surfactant mixtures, relative to pure (unmixed) cationic and anionic surfactants, results from the mixtures' enhanced flexibility in tailoring the physicochemical properties of the interface. To judiciously employ these mixtures, it is necessary to characterize the structure-function property relationship of their surfactant monolayers that lend to oil-tolerant/intolerant foams.