The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information.

Motivation: Knowledge graphs (KGs) are being adopted in industry, commerce and academia. Biomedical KG presents a challenge due to the complexity, size and heterogeneity of the underlying information.

Results: In this work, we present the Scalable Precision Medicine Open Knowledge Engine (SPOKE), a biomedical KG connecting millions of concepts via semantically meaningful relationships.

Acute Pulmonary Embolism in an Intensive Care Unit Setting in Sierra Leone.

Introduction: In Sierra Leone, the lack of information on pulmonary embolism (PE) limits the access to evidence-based standard of diagnostic work-up and management of the disease. The objective of this study was to describe the clinical characteristics and management of acute pulmonary embolism in our setting and to determine whether the pre-test probability scoring algorithms were used prior to Computed Tomography Pulmonary Angiogram (CTPA) request.

Methods: This retrospective observational study was conducted on CTPA-confirmed PE patients admitted to the Intensive Care Unit, Choithrams Memorial Hospital, in Freetown, Sierra Leone between July 2014 to June 2019.

Persistent left superior vena cava in a 29-year-old lady with Ebstein's anomaly and complete heart block. A case report and literature review.

Introduction: Persistent Left Superior Vena Cava (PLSVC) is a rare congenital vascular anomaly that may occur alone or in combination with complex congenital heart anomalies and dangerous arrhythmias. We report the first case in the literature of combined PLSVC, Ebstein's Anomaly (Type A) and complete atrioventricular block in an adult female, being successfully managed with permanent pacemaker implantation in Sierra Leone.

Case Summary: We present an interesting case of a 29-year-old female, referred to the cardiology clinic on account of breathlessness, dizziness, and recurrent syncope.

Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis.

Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world's aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients' pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use.