Publications by authors named "K Beraki"
Article Synopsis
- * Flow cytometry was used to classify immune cells in NSCLC tumors, revealing 13 immune cell types, with T cells being dominant (47% of immune cells), and B cells being the second most common type (16%).
- * The study highlights significant findings, such as B cells being more abundant in NSCLC tumors compared to non-cancerous lung tissue, while macrophages and NK cells were less frequent in tumors, suggesting complex immune interactions that could influence therapy.
Tumor-associated macrophages may either promote or suppress tumor growth depending on their activation status. Interferon-γ (IFN-γ) has been identified as a key factor for inducing tumoricidal M1 phenotype in macrophages. However, it remains unclear whether IFN-γ is sufficient or if additional stimuli are required.
View Article and Find Full Text PDFPurpose: To examine the endothelium of donor corneas with extended postmortem time for survival and reparative mechanisms in an eye bank organ culture storage system.
Methods: We obtained 14 pairs of donor corneas with a postmortem time ranging from 29 to 163 hours. One cornea of a pair was immediately fixed for the study of structural changes postmortem and to serve as a control.
Purpose: The maximum post-mortem time limit for obtaining donor corneas varies between eye banks. It is not known for how long a time the epithelial cells survive post-mortem, nor is it known if donor corneas with extended post-mortem time are able to regenerate the epithelium. Therefore, we wanted to examine the epithelium in donor corneas for regenerative ability during storage in an eye bank organ culture system.
View Article and Find Full Text PDFCytokine systems are activated in heart failure, and it is believed that interaction between such systems may be important during progression of this disorder. We have previously shown that failing hearts have increased levels of the interleukin-6 related cytokine leukemia inhibitory factor (LIF) and activin A, a member of the transforming growth factor-beta family. The aim of this study was to examine the effects of activin A on cardiomyocytes and a potential interaction with LIF-mediated changes in cell signaling and growth.
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