Publications by authors named "K Bednarek"
Pain accompanying medical procedures can be considered in the "mind-body" problem of accounting for and describing the relationship between mental and physical processes (psyche and soma). : The purpose of this study is to evaluate the severity of pain among patients undergoing a minihysteroscopy procedure under local anesthesia using the "GUBBINI SYSTEM" (GUBBINI Mini Hystero-Resectoscope; Tontarra Medizintechnik, Tuttlingen, Germany) and to assess the association of various covariates with pain during the procedure, including patient emotional state. This study included 171 patients admitted to the Center for Hysteroscopy under Local Anesthesia at the Heliodor Święcicki Gynecological and Obstetrical Clinical Hospital of the Karol Marcinkowski Medical University in Poznań, Poland, for hysteroscopic treatment under local anesthesia (paracervical, using lignocaine).
View Article and Find Full Text PDFIntroduction: Cervical insufficiency accounts for 15% of recurrent pregnancy losses between 16 and 28 weeks of gestation. The aim of the study is to verify the effectiveness of emergency double-level cerclage with vaginal progesterone in cervical insufficiency treatment in terms of the prevention of preterm delivery before 34 weeks of gestation.
Methods And Analysis: This trial is a multicentre, non-blinded, randomised study with 1:1 allocation ratio.
Article Synopsis
- Proteasome inhibitors, like bortezomib and carfilzomib, are powerful treatments for multiple myeloma, but resistance to these drugs poses a significant challenge in therapy.
- This study generated resistant myeloma cell lines to analyze differences in their response and associated mechanisms compared to sensitive cell lines.
- Findings revealed distinct proteomic profiles and functional variances between the resistant cell lines, with differences in proteasome activity and responses to oxidative stress that could influence treatment effectiveness.
Alterations of the cell cycle checkpoints lead to uncontrolled cell growth and result in tumorigenesis. One of the genes essential for cell proliferation and cell cycle regulation is . This makes it a potential target in cancer therapy.
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