Label-free highly multimodal nonlinear endoscope.

We demonstrate a 2 mm diameter highly multimodal nonlinear micro-endoscope allowing label-free imaging of biological tissues. The endoscope performs multiphoton fluorescence (3-photon, 2-photon), harmonic generation (second-SHG and third-THG) and coherent anti-Stokes Raman scattering (CARS) imaging over a field of view of 200 µm. The micro-endoscope is based on a double-clad antiresonant hollow core fiber featuring a high transmission window (850 nm to 1800 nm) that is functionalized with a short piece of graded-index (GRIN) fiber.

Cu/Ce-co-Doped Silica Glass as Radioluminescent Material for Ionizing Radiation Dosimetry.

Optically activated glasses are essential to the development of new radiation detection systems. In this study, a bulk glassy rod co-doped with Cu and Ce ions, was prepared via the sol-gel technique and was drawn at about 2000 °C into a cylindrical capillary rod to evaluate its optical and radioluminescence properties. The sample showed optical absorption and photoluminescence (PL) bands attributed to Cu and Ce ions.

Double clad tubular anti-resonant hollow core fiber for nonlinear microendoscopy.

We report the fabrication and characterization of the first double clad tubular anti-resonant hollow core fiber. It allows to deliver ultrashort pulses without temporal nor spectral distortions in the 700-1000 nm wavelength range and to efficiently collect scattered light in a high numerical aperture double clad. The output fiber mode is shaped with a silica microsphere generating a photonic nanojet, making it well suitable for nonlinear microendoscopy application.

Polarization-maintaining and single-mode large mode area pixelated Bragg fiber.

This Letter reports on a large mode area pixelated Bragg fiber in which some high refractive index rods were replaced by boron-doped rods that allows polarization maintaining behavior while keeping single-mode behavior. The realized all-solid fiber has a core diameter of 35 µm. The fundamental mode is circular with a 25 µm mode field diameter around 1 µm wavelength, and the polarization extinction ratio reaches 30 dB.

A tunable filter for high molecular weight DNA selection and linked-read sequencing.

In third generation sequencing, the production of quality data requires the selection of molecules longer than ∼20 kbp, but the size selection threshold of most purification technologies is smaller than this target. Here, we describe a technology operated in a capillary with a tunable selection threshold in the range of 3 to 40 kbp controlled by an electric field. We demonstrate that the selection cut-off is sharp, the purification yield is high, and the purification throughput is scalable.