Patients with DCIS Seen at a Specialized High-Risk Breast Clinic Run by Surgical Advanced Practice Providers Have High Rates of Preventive Medication Uptake.

Background: Preventative medication (PM) uptake is low among patients at an elevated risk of breast cancer, largely due to fears of intolerance. This study aimed to investigate whether a new, surgical advanced practice provider (APP)-run clinic was effectively prescribing PM. We hypothesized equivalent rates of PM uptake compared to consultation with medical oncologists (MD).

Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6.

Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups of genetic similarity provided by All of Us: African/African American (AFR), Admixed American/Latino (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), or South Asian (SAS). We observed that germline susceptibility to cancer consistently replicates in EUR-like participants but less so in other participants. We found that All of Us participants from the EUR (p = 1.

Complications Following Open Versus Minimally Invasive Resection of Gastric Adenocarcinoma.

Background And Objectives: Gastric adenocarcinoma (GA) is commonly treated with open or minimally invasive surgery (MIS). The preferred surgical approach remains unclear. This study sought to assess utilization over time, compare complication rates by surgical approach, and identify predictors of experiencing complications.

Changes in pressure distribution of the solar surface after a single trimming event are associated with external hoof measurements in the equine fore foot.

Background: Trimming is critical for a functioning equine hoof. Pressure distribution provides information on loading; however, information on the effects of trimming on pressure distribution is lacking.

Objectives: To describe the pressure changes of equine fore feet following trimming.

Running performance in Australopithecus afarensis.

The evolution of bipedal gait is a key adaptive feature in hominids, but the running abilities of early hominins have not been extensively studied. Here, we present physics simulations of Australopithecus afarensis that demonstrate this genus was mechanically capable of bipedal running but with absolute and relative (size-normalized) maximum speeds considerably inferior to modern humans. Simulations predicted running energetics for Australopithecus that are generally consistent with values for mammals and birds of similar body size, therefore suggesting relatively low cost of transport across a limited speed range.