Publications by authors named "K Bakos"
Article Synopsis
- Epidural opioids, such as methadone and morphine, are used for managing acute postoperative pain, but this study investigates whether methadone provides better localized pain relief (segmental analgesia) than morphine.
- In the study, 13 healthy volunteers received epidural injections of either 4 mg of methadone or morphine and their pain tolerance was tested across different body regions for 24 hours.
- Results showed no significant difference in localized pain relief between the two drugs, although morphine resulted in longer-lasting analgesia and more systemic side effects compared to methadone, which had a better side effect profile.
In this study, the disrupting effects of glyphosate (GLY), aminomethylphosphonic acid (AMPA), and three glyphosate-based herbicides (GBHs) on vitellogenesis in a non-concentration-dependent manner are reported for the first time in 120 h of acute exposure of zebrafish at environmentally relevant concentrations. GBHs are commonly used worldwide in weed control management. Due to their extensive application, they frequently occur in aquatic ecosystems and may affect various organisms.
View Article and Find Full Text PDFFever Characteristics and Impact on Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy.
Clin Lymphoma Myeloma Leuk
January 2023
Background: Fever is a hallmark symptom of cytokine release syndrome (CRS) after chimeric antigen receptor (CAR) T-cell therapy. Fever characteristics and the impact of fever on safety and efficacy post CAR T are not well understood. We sought to explore the impact of fever and its characteristics on safety and efficacy post CAR T-cell therapy.
View Article and Find Full Text PDFAflatoxin B1 (AFB1) is a potent mycotoxin and natural carcinogen. The primary producers of AFB1 are and Sterigmatocystin (STC), another mycotoxin, shares its biosynthetic pathway with aflatoxins. While there are abundant data on the biological effects of AFB1, STC is not well characterised.
View Article and Find Full Text PDFObjectives: Intravenous lidocaine can alleviate painful diabetic peripheral neuropathy (DPN) in some patients. Whether quantitative sensory testing (QST) can identify treatment responders has not been prospectively tested.
Materials And Methods: This was a prospective, randomized, double-blind, crossover, placebo-controlled trial comparing intravenous lidocaine to normal saline (placebo) for painful DPN.