Publications by authors named "K B Zarnke"
Background: People with kidney failure often require surgery and experience worse postoperative outcomes compared to the general population, but existing risk prediction tools have excluded those with kidney failure during development or exhibit poor performance. Our objective was to derive, internally validate, and estimate the clinical utility of risk prediction models for people with kidney failure undergoing non-cardiac surgery.
Design, Setting, Participants, And Measures: This study involved derivation and internal validation of prognostic risk prediction models using a retrospective, population-based cohort.
Article Synopsis
- - This scoping review focuses on the challenges and postoperative outcomes for people with chronic kidney disease and dialysis (CKD-G5D) when they undergo surgery, highlighting the need for tailored perioperative management strategies.
- - Researchers analyzed 183 studies, mainly randomized controlled trials, finding that most if focused on kidney transplantation and dialysis vascular access, with key areas like fluid management and imaging being emphasized.
- - The review indicates there are significant gaps in perioperative research for CKD-G5D patients but notes a growing body of evidence, mainly from non-randomized studies, which could help improve perioperative care pathways in the future.
Background: People with kidney failure have a high incidence of major surgery, though the risk of perioperative outcomes at a population-level is unknown. Our objective was to estimate the proportion of people with kidney failure that experience acute myocardial infarction (AMI) or death within 30 days of major non-cardiac surgery, based on surgery type.
Methods: In this retrospective population-based cohort study, we used administrative health data to identify adults from Alberta, Canada with major surgery between April 12,005 and February 282,017 that had preoperative estimated glomerular filtration rates (eGFRs) < 15 mL/min/1.
Optical coherence tomography of the eye suggests the retina thins in normal pregnancy. Our objectives were to confirm and extend these observations to women with hypertensive disorders of pregnancy (HDP). Maternal demographics, clinical/laboratory findings and measurements of macular thickness were repeatedly collected at gestational ages <20 weeks, 20-weeks to delivery, at delivery and postpartum.
View Article and Find Full Text PDFImportance: Severe acute kidney injury (AKI) is a serious postoperative complication. A tool for predicting the risk of AKI requiring kidney replacement therapy (KRT) after major noncardiac surgery might assist with patient counseling and targeted use of measures to reduce this risk.
Objective: To derive and validate a predictive model for AKI requiring KRT after major noncardiac surgery.