Publications by authors named "K B Thor"
Substantial clinical and preclinical evidence indicates that transient receptor potential vanilloid 1 (TRPV1) receptors are expressed on terminals of colorectal chemoreceptors and mechanoreceptors and are involved in various rectal hypersensitivity disorders with common features of colorectal overactivity. These stimulatory properties of TRPV1 receptors on colorectal function suggested that brief stimulation of TRPV1 might provide a means of pharmacologically activating the colorectum to induce defecation in patients with an "unresponsive" colorectum. The current studies explored the basic features of TRPV1 receptor-induced contractions of the colorectum in anesthetized rats with and without acute spinal cord injury (aSCI).
View Article and Find Full Text PDFOne cannot survive without regularly urinating and defecating. People with neurologic injury (spinal cord injury, traumatic brain injury, stroke) or disease (multiple sclerosis, Parkinson's disease, spina bifida) and many elderly are unable to voluntarily initiate voiding. The great majority of them require bladder catheters to void urine and "manual bowel programs" with digital rectal stimulation and manual extraction to void stool.
View Article and Find Full Text PDFStudy Design: Preclinical pharmacology.
Objectives: To determine whether blocking substance P signaling attenuates the hypertension and bradycardia evoked by colorectal distension (CRD) in spinal cord injured (SCI) rats.
Setting: University laboratory in Pennsylvania, U.
Article Synopsis
- The order of rust fungi includes over 7,000 species that significantly affect agriculture, horticulture, forestry, and ecosystems.
- Phakopsora pachyrhizi, the fungus responsible for Asian soybean rust disease, is a prime example of this impact and has a complex genome that has been challenging to assemble accurately.
- Researchers sequenced three genomes of P. pachyrhizi, revealing a size of up to 1.25 Gb and a high transposable element content (~93%), demonstrating the role of these elements in host adaptation, stress responses, and genetic variability.
The feasibility of eliciting defecation and urination after intranasal (IN) or sublingual (SL) delivery of a small peptide NK2 receptor agonist, [Lys, MeLeu, Nle]-NKA, was examined using prototype formulations in dogs. In anesthetized animals, administration of 100 or 300 µg/kg IN or 2.0-6.
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