Publications by authors named "K B Parent"

Podophages are, by far, the least well studied of all the bacteriophages. Despite being classified together due to their short, noncontractile tails, there is a huge amount of diversity among members of this group. Of the podophages, the N4-like family is the least well studied structurally and is quite divergent from well-characterized podophages such as T7 and P22.

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National science, technology, engineering, and mathematics education emphasizes science practices, such as hands-on learning. We describe a week-long activity where students participate in real-world scientific discovery, including "hunting" for bacteriophage in a variety of environmental samples. First, the students collect samples, then look for evidence of phage on "bait" bacteria, and finally amplify/purify the phages for further study.

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Article Synopsis
  • Tupanviruses are a type of virus that infect special cells in the immune system called phagocytes.
  • Scientists discovered how certain metal ions and hydrogen peroxide can cause these viruses to open up in a specific way.
  • This opening might release the part of the virus that is needed to start an infection, making the treated viruses no longer able to infect cells.
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  • The delivery of small interfering RNAs (siRNAs) for gene-targeted therapies faces challenges due to their inability to penetrate cell membranes, especially in lymphocytes.
  • A novel lipid-conjugated polyethylenimine lipopolymer platform was developed to enhance the delivery of siRNAs, forming stable complexes called lipopolymer nanoparticles (LPNPs).
  • Tests in both human blood cells and acute lymphoblastic leukemia models showed that LPNPs effectively silenced specific genes, induced cancer cell death, and reduced tumor sizes while maintaining a safe profile without triggering inflammatory responses.
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Phage satellites commonly remodel capsids they hijack from the phages they parasitize, but only a few mechanisms regulating the change in capsid size have been reported. Here, we investigated how a satellite from , phage-inducible chromosomal island-like element (PLE), remodels the capsid it has been predicted to steal from the phage ICP1 (Netter et al., 2021).

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