Publications by authors named "K B Neal"
Bexicaserin is a highly selective agonist at the 5-HT receptor in clinical development for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). We report an LC-MS/MS method for the quantitative estimation of bexicaserin in human plasma and urine. The sample preparation involves the extraction of bexicaserin and internal standard (CD-bexicaserin; IS) from 150 μL plasma and 50 μL urine using a solid phase extraction method.
View Article and Find Full Text PDFPurpose: Non-fusion surgical options for pediatric scoliosis management such as vertebral body tethering (VBT) offer an alternative to spinal fusion. With this study, we aim to evaluate the postoperative outcomes in boys versus girls who have undergone VBT. Our hypothesis is that girls and boys will have similar outcomes by 2-year follow-up.
View Article and Find Full Text PDFThe persisting life-expectancy 'gap' between First Nations and non-First Nations Australians is fundamentally driven by the social determinants of health. These include income and social protection, access to adequate housing and food security, among others. These factors are particularly prominent in Central Australia.
View Article and Find Full Text PDFFirst reported case of multiple endocrine neoplasia type 1 in an Australian Aboriginal.
Endocrinol Diabetes Metab Case Rep
July 2024
Article Synopsis
- - The case study discusses a 48-year-old Aboriginal Australian woman diagnosed with Multiple Endocrine Neoplasia type 1 (MEN1), who faced significant health issues including hypercalcaemia, following a history of parathyroid surgery and several severe medical conditions, indicating the complexity of her case.
- - Genetic testing revealed a rare variant in the MEN1 gene, but cultural and logistical challenges hindered effective genetic counseling for her family, highlighting gaps in healthcare support for remote Aboriginal communities.
- - The case underscores the critical need for improved genetic counseling approaches and timely recognition of rare diseases in remote areas, as late diagnoses can lead to severe health consequences, as seen in her unfortunate passing in 2021.