Publications by authors named "K B Murphy"
Designers are increasingly tasked to reduce the carbon footprint of buildings. While core disciplines (e.g.
View Article and Find Full Text PDFObjectives: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agonists and may similarly affect the efficacy of GIPR agonists. We explored the extent of pancreatic GIPR functional desensitisation with sustained agonist exposure.
View Article and Find Full Text PDFObjective: The study aims to assess the effect of intrauterine metformin exposure on offspring adiposity measures in childhood.
Design: Systematic review and meta-analysis.
Data Sources: Medline, Embase and Cochrane Central were searched from inception to 4 October 2024.
Article Synopsis
- The project focused on reducing surgical site infections (SSIs) in pediatric patients undergoing cardiothoracic surgery to less than 1 per 100 cases.
- A multidisciplinary team identified risk factors and created a quality improvement (QI) initiative, which included enhanced hygiene practices and wound care education.
- The result was a significant decrease in SSIs, dropping from 2.82 to 0.55 per 100 cases, without any increase in major complications or mortality.
Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (MASH), is a major risk factor for cirrhosis and hepatocellular carcinoma (HCC) and a leading cause of liver transplantation. MASH is caused by an accumulation of toxic fat molecules in the hepatocyte which leads to inflammation and fibrosis. Inadequate human "MASH in a dish" models have limited our advances in understanding MASH pathogenesis and in drug discovery.
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