Publications by authors named "K B Gutzkow"
Article Synopsis
- * This study aimed to find genetic variations (SNPs and CNVs) affecting how children metabolize phthalates by analyzing data from 1,044 children in the HELIX cohort.
- * Significant genetic loci associated with phthalate metabolism were identified, along with genes related to detoxification processes and renal excretion, suggesting a strong genetic component influencing how these compounds are processed in the body.
Background: Prenatal ethylene oxide exposure may have adverse effects on fetal development. We examined the relationships between ethylene oxide hemoglobin (Hb) adduct levels and offspring's size at birth in a prospective European mother-child study.
Methods: This study included 1106 singletons from the NewGeneris project (2006-2010) with ethylene oxide Hb adducts measured in cord blood.
Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals.
View Article and Find Full Text PDFBackground: Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental exposures on health are limited by the diversity of exposures included, especially for early life determinants. We used machine learning methods to build early life exposome risk scores for three health outcomes using environmental, molecular, and clinical data.
View Article and Find Full Text PDFArticle Synopsis
- Mercury is widely used in industry and products, leading to significant environmental contamination and occupational exposure, with genetic factors potentially influencing how it is absorbed and metabolized in the body.
- A study analyzed blood mercury levels in pregnant women and children to identify genetic variations (SNPs) linked to mercury concentrations, finding an estimated heritability of 24% in pregnant women but not in children.
- The research identified 16 SNPs connected to mercury levels in pregnant women and 21 in children, but there was no significant overlap or conclusive results, suggesting differences in metabolism and the need for further validation of these findings.