'The Stegosaurus Appearance' on ultrasound to assist in identifying the correct spinal level for primary lumbar spinal surgery.

Lumbar spinal surgery relies on palpation of anatomical landmarks and X-ray imaging confirmation to identify the correct spinal level, therefore exposing patients and staff to radiation, and increasing intraoperative time and cost. Ultrasound (US) assistance is being used to visualise spinal anatomy by many specialities, such as neurology and anaesthetics, and can be used intraoperatively in selected spinal surgery cases. However, its potential use to check spinal levels prior to surgery remains understudied.

The inductive effect does not explain electron density in haloacetates: are our textbooks wrong?

The inductive effect is a central concept in chemistry and is often exemplified by the p values of acetic acid derivatives. The reduction in p is canonically attributed to the reduction in the electron density of the carboxylate group through the inductive effect. However, wave functional theory calculations presented herein reveal that the charge density of the carboxylate group is not explained by the inductive effect.

Molecular basis of human angiotensin-1 converting enzyme inhibition by a series of diprolyl-derived compounds.

Angiotensin-1-converting enzyme (ACE) is a zinc-dependent carboxypeptidase of therapeutic interest for the treatment of hypertension, inflammation and fibrosis. It consists of two homologous N and C catalytic domains, nACE and cACE, respectively. Unfortunately, the current clinically available ACE inhibitors produce undesirable side effects due to the nonselective inhibition of these domains.

Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.

Metabotropic glutamate receptors are a family of eight class C G protein-coupled receptors regulating higher order brain functions including cognition and motion. Metabotropic glutamate receptors have thus been heavily investigated as potential drug targets for treating neurological disorders. Drug discovery efforts directed toward metabotropic glutamate receptor subtype 5 (mGlu) have been particularly fruitful, with a wealth of drug candidates and pharmacological tools identified.

The Influence of Burnout, Resilience, and Resources to Support Clinical Practice Among Newly Licensed Nurses Intended Job Plans.

Objective: Survey newly licensed nurses (NLNs) with respect to burnout, resilience, perception of the work environment, and intended short- and long-term job plans.

Background: NLN retention is a significant contributing factor to the nursing shortage.

Methods: A 126-item survey measuring demographics, burnout, resilience, work environment, and job plans distributed via email, using Listservs to recruit nurses licensed for 5 years or less.