eQTL in diseased colon tissue identifies novel target genes associated with IBD.

Genome-wide association studies (GWAS) have identified over 300 loci associated with the inflammatory bowel diseases (IBD), but putative causal genes for most are unknown. We conducted the largest disease-focused expression quantitative trait loci (eQTL) analysis using colon tissue from 252 IBD patients to determine genetic effects on gene expression and potential contribution to IBD. Combined with two non-IBD colon eQTL studies, we identified 194 potential target genes for 108 GWAS loci.

Effect of Wave Dark Matter on Equal Mass Black Hole Mergers.

For dark matter to be detectable with gravitational waves from binary black holes, it must reach higher than average densities in their vicinity. In the case of light (wavelike) dark matter, the density of dark matter between the binary can be significantly enhanced by accretion from the surrounding environment. Here we show that the resulting dephasing effect on the last ten orbits of an equal mass binary is maximized when the Compton wavelength of the scalar particle is comparable to the orbital separation, 2π/μ∼d.

Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model.

Background: Environmental exposure to peanut through non-oral routes is a risk factor for peanut allergy. Early-life exposure to air pollutants, including particulate matter (PM), is associated with sensitization to foods through unknown mechanisms. We investigated whether PM promotes sensitization to environmental peanut and the development of peanut allergy in a mouse model.

Differential Susceptibility to Benzo[a]pyrene Exposure during Gestation and Lactation in Mice with Genetic Variations in the Aryl Hydrocarbon Receptor and Genes.

Polycyclic aromatic hydrocarbons are ubiquitous air pollutants, with additional widespread exposure in the diet. PAH exposure has been linked to adverse birth outcomes and long-term neurological consequences. To understand genetic differences that could affect susceptibility following developmental exposure to polycyclic aromatic hydrocarbons, we exposed mice with variations in the aryl hydrocarbon receptor and the three CYP1 enzymes from gestational day 10 (G10) to weaning at postnatal day 25 (P25).

Well-Posedness of the Four-Derivative Scalar-Tensor Theory of Gravity in Singularity Avoiding Coordinates.

We show that the most general scalar-tensor theory of gravity up to four derivatives in 3+1 dimensions is well-posed in a modified version of the CCZ4 formulation of the Einstein equations in singularity-avoiding coordinates. We demonstrate the robustness of our new formulation in practice by studying equal mass black hole binary mergers for different values of the coupling constants. Although our analysis of well-posedness is restricted to cases in which the couplings are small, we find that in simulations we are able to push the couplings to larger values, so that a certain weak coupling condition is order one, without instabilities developing.