Publications by authors named "K B Casaletto"
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.
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- Aberrant angiogenesis may contribute to cognitive decline and could serve as a therapeutic target for dementia prevention, though most prior studies have focused on animal models.
- This study evaluated the relationship between blood markers of angiogenesis and cognitive aging in a sample of 435 older adults, revealing significant associations that varied by sex, particularly in younger women compared to men.
- Results indicated that higher levels of certain angiogenic markers were linked to better executive function and less brain atrophy, suggesting the potential for targeting angiogenesis in addressing age-related cognitive impairment.
Article Synopsis
- There is an increasing awareness of the early stages of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to new efforts aimed at prevention, largely driven by the participation of individuals at genetic risk. !* -
- A recent workshop outlined recommendations for clinical care and lifestyle management tailored to those at elevated risk for ALS and FTD, covering aspects such as genetic testing, early symptom monitoring, and FDA-approved treatments. !* -
- The guidance document seeks to inform both patients and healthcare providers about best practices and highlights the need for further research to strengthen evidence for future recommendations. !*
Article Synopsis
- The aging brain's cognitive abilities are influenced by a balance between protective lifestyles and the accumulation of brain pathologies, especially in Alzheimer's disease.
- A study involving 440 participants used advanced methods to analyze the relationships between physical activity, cognitive function, and specific brain changes after death.
- Key findings revealed that synaptic peptides are critical for understanding cognitive decline, with lower physical activity linked to greater negative impacts between tau pathology and synaptic health in older adults.
Article Synopsis
- - Cardiovascular health, evaluated through Life's Simple 7 (LS7), is linked to slower cognitive decline and better brain integrity in patients with autosomal dominant frontotemporal lobar degeneration (FTLD).
- - A study involving 247 FTLD genetic variant carriers and 189 non-carrier controls found that those with better cardiovascular health had slower memory and language declines, as well as less accumulation of frontal white matter hyperintensities (WMHs).
- - Maintaining good cardiovascular health could be a key modifiable strategy to improve cognitive outcomes and brain health in individuals at risk for genetic forms of dementia.