Publications by authors named "K B Cahill"
Action video games foster competitive environments that demand rapid spatial navigation and decision-making. Action video gamers often exhibit faster response times and slightly improved accuracy in vision-based sensorimotor tasks. However, the underlying functional and structural changes in the two visual streams of the brain that may be contributing to these cognitive improvements have been unclear.
View Article and Find Full Text PDFIntroduction: Polypharmacy can be considered the norm in elderly patients, because older individuals experience an increasing number of concomitant respiratory and non-respiratory diseases other than asthma, carrying the risk of drug-to-drug-interactions and drug-to-comorbidities interactions. In this context, asthma in older adults, conventionally aging >65 years of age, cannot be adequately managed without considering their individual characteristics, as these challenge the traditional therapeutic algorithms/management strategies commonly applied to younger populations.
Areas Covered: The current article aims at addressing pitfalls and advantages of current pharmacological strategies in older individuals with asthma.
CRS patients with asthma show differential nasal mucus cytokine signatures based on endotype. IL-7 concentration is positively associated with higher %FEV1 and %FVC in CRS patients with asthma.
View Article and Find Full Text PDFArticle Synopsis
- - This study examines the effectiveness of traditional versus advanced methods for analyzing asthma-related data from electronic health records (EHR), highlighting the importance of data quality for real-world evidence in healthcare research.
- - Researchers extracted 18 specific asthma-related features from a large dataset of patient encounters and found that advanced artificial intelligence methods significantly outperformed traditional methods in accuracy, with a notable increase in F1-score from 52.2% to 94.7%.
- - The results suggest that utilizing advanced data analysis techniques can enhance the quality of real-world datasets in asthma research, providing more detailed insights into disease subtypes and symptoms, ultimately supporting better healthcare decisions.
Background: Anti-inflammatory effects of incretin signaling through the glucagon-like peptide-1 receptor (GLP-1R) and the glucose-dependent insulinotropic polypeptide receptor (GIPR) in mice have been reported. Therefore, we hypothesized that signaling through the endogenous GLP-1R and the GIPR individually decreases allergic airway inflammation and that the combination of GLP-1R and GIPR signaling together additively inhibits allergen-induced lung and airway inflammation.
Methods: WT (C57BL/6J), GLP-1R knockout (KO), GIPR KO, and GLP-1R/GIPR double KO (DKO) mice were challenged intranasally with Alternaria alternata extract (Alt-Ext) or vehicle to evaluate the impact of signaling through these receptors on the innate allergen-induced inflammatory response that is primarily driven by group 2 innate lymphoid cells (ILC2).