Publications by authors named "K B Beckman"
Background: Previous research showed that 5-hydroxytryptophan (5HTP), a metabolic precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration across endothelial monolayers.
Objective: It is unknown if serotonin receptors are involved in mediating this 5HTP function or if serotonin receptor (HTR) single nucleotide polymorphisms (SNPs) associate with lung function in humans.
Methods: Serotonin receptor subtypes were assessed by qPCR, western blot, confocal microscopy, pharmacological inhibitors and siRNA knockdown.
The eyelid margin is vital to ocular surface integrity. Much peer-reviewed literature has been established in eyelid margin inflammation, better known as blepharitis. The purpose was to review and understand the impact of eyelid margin disease.
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- - Metformin shows antiviral properties against SARS-CoV-2 by inhibiting protein translation through the mechanistic target of rapamycin pathway, leading to significant reductions in hospitalizations, emergency visits, and long COVID risk in the COVID-OUT trial.
- - The COVID-OUT trial involved 999 participants and compared metformin, fluvoxamine, and ivermectin; it found a 3.6-fold reduction in viral load with metformin compared to placebo, and reduced rates of detectable viral load and viral rebound.
- - The results indicate that metformin effectively lowers SARS-CoV-2 viral load, potentially explaining its clinical effectiveness, while neither ivermectin nor fluvoxamine showed significant benefits over placebo.
The Dietary Guidelines for Americans (DGA) provides science-based advice on dietary intake to promote health, reduce risk of chronic disease, and meet nutrient needs. It is jointly published by the United States Departments of Health and Human Services and Agriculture (USDA) every 5 y. As chronic diseases continue to rise to pervasive levels, helping the United States population follow the DGA is especially important for improving the health of our nation.
View Article and Find Full Text PDFBlepharitis is a common ophthalmic condition with multiple etiologies and no definitive, universal treatment. The treatment modalities for managing lid margin diseases vary depending on the disease's cause, location, and severity. For anterior blepharitis, management options include eyelid hygiene with warm compresses, eyelid scrubs, baby shampoo, and over-the-counter eyelid cleansers.
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