Publications by authors named "K Azarow"
The process of developing a comprehensive maternal-fetal surgery center.
Am J Obstet Gynecol MFM
November 2024
Article Synopsis
- Fetal therapy has evolved to include treatments for complex fetal disorders, leading to the establishment of specialized maternal-fetal surgery centers across the country.
- These centers adopt a multidisciplinary approach to prioritize both the safety of pregnant patients and the health of the fetus.
- While existing literature outlines what makes an effective center, there’s a lack of guidance on how to actually create one, highlighting the complex and resource-intensive journey involved in building these facilities.
Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly often accompanied by other structural anomalies and/or neurobehavioral manifestations. Rare de novo protein-coding variants and copy-number variations contribute to CDH in the population. However, most individuals with CDH remain genetically undiagnosed.
View Article and Find Full Text PDFBackground: Congenital diaphragmatic hernia (CDH) accounts for 8% of all major congenital anomalies. Neonates who are small for gestational age (SGA) generally have a poorer prognosis. We sought to identify risk factors and variables associated with outcomes in neonates with CDH who are SGA in comparison to neonates who are appropriate for gestational age (AGA).
View Article and Find Full Text PDFPurpose: The purpose of this study was to investigate factors impacting transplant-free survival among infants with biliary atresia.
Methods: A multi-institutional, retrospective cohort study was performed at nine tertiary-level children's hospitals in the United States. Infants who underwent Kasai portoenterostomy (KP) from January 2009 to May 2017 were identified.
Article Synopsis
- * A study found important genetic variants in the LONP1 and ALYREF genes, with LONP1 showing a significant role in CDH risk through both new and rare inherited mutations.
- * Research on mice lacking Lonp1 revealed severe lung issues, supporting the gene's critical role in lung development and the associated high mortality in CDH cases.