Lived experiences of healthcare. Putting the person in person centred care in the medical radiation sciences.

Introduction: Contemporary healthcare models recognise person-centred care (PCC) as a fundamental principle of quality, safe care. While substantial literature exists on PCC in healthcare generally, there is less evidence on how this relates to medical imaging and radiation therapy. Embedding patient-lived experiences of healthcare into healthcare education has promise in enhancing students' confidence in delivering PCC.

Addressing vulnerability and exclusion in the South African small-scale fisheries sector: does the current regulatory framework measure up?

Small-scale fishers and fishing communities have long suffered marginalisation and discrimination in South Africa. New laws and policies promulgated as the result of a court case brought by small-scale fishers, NGOs and academics attempt to rectify this problem. Drawing on the poverty-vulnerability-marginalisation framework, the paper considers whether this regulatory regime reduces vulnerability and marginalisation within the sector as an important precursor to poverty reduction initiatives, such as improved rights allocation.

Estrogen-related receptor α regulates osteoblast differentiation via Wnt/β-catenin signaling.

Based on its homology to the estrogen receptor and its roles in osteoblast and chondrocyte differentiation, the orphan nuclear receptor estrogen-related receptor α (ERRα (ESRRA)) is an intriguing therapeutic target for osteoporosis and other bone diseases. The objective of this study was to better characterize the molecular mechanisms by which ERRα modulates osteoblastogenesis. Experiments from multiple systems demonstrated that ERRα modulates Wnt signaling, a crucial pathway for proper regulation of bone development.

Transcriptional regulation by the proteasome as a mechanism for cellular protein homeostasis.

Protein degradation mediated by the ubiquitin-proteasome system is a vitally important means of regulation for many cellular processes. An increasing body of evidence implicates the proteasome in the regulation of gene transcription through a variety of mechanisms, including transcription factor processing and proteasome-chromatin association. Recently a genomic approach was used to elucidate the transcriptional effects of the proteasome in budding yeast.

The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.

The regulation of cellular membrane dynamics is crucial for maintaining proper cell growth and division. The Cdc48-Npl4-Ufd1 complex is required for several regulated membrane-associated processes as part of the ubiquitin-proteasome system, including ER-associated degradation and the control of lipid composition in yeast. In this study we report the results of a genetic screen in Saccharomyces cerevisiae for extragenic suppressors of a temperature-sensitive npl4 allele and the subsequent analysis of one suppressor, GET3/ARR4.