Publications by authors named "K Ashizawa"
A 63-year-old woman undergoing peritoneal dialysis (PD) presented to our hospital with abdominal pain, diarrhea, and cloudy PD effluent. An elevated white blood cell count in the PD effluent led to a diagnosis of PD-associated peritonitis. She was subsequently started on intraperitoneal cefazolin and ceftazidime, after which her condition improved rapidly.
View Article and Find Full Text PDFObjective: The aim of this special report is to describe the 6th edition of "The Guidelines for the Management of Pulmonary Nodules Detected by Low-Dose CT Lung Cancer Screening ".
Methods: Since the 5th edition six years ago, a review of the literature and consideration of consistency with new evidence led to the revision of the 6th edition.
Results: The main revisions in the 6th edition can be summarized as follows: 1) addition of the section "Recommendations for Low-Dose CT Lung Cancer Screening in Japan"; 2) change in the recommended solid component diameter, and follow-up interval for nodules with a total mean diameter of less than 15 mm and a solid component diameter of less than 8 mm; 3) replacement of the recommended case images; and 4) introduction of the criteria of the Lung Cancer CT Screening Certification Organization.
Article Synopsis
- Pulmonary alveolar proteinosis (PAP) is a rare lung disease caused by the buildup of surfactant in the alveoli, often identified by a specific "crazy-paving" pattern on CT scans.
- An 80-year-old woman presented with multiple localized ground glass opacities (GGOs) on CT, which raised suspicion of pulmonary adenocarcinoma due to one lesion's growth.
- After surgery (right upper lobectomy), the diagnosis of PAP was confirmed despite the unusual appearance of the GGOs, emphasizing the need to consider PAP in similar cases.
Although opioid analgesics are indispensable in treating pain, these drugs are accompanied by life-threatening side effects. While clinically relevant opioid drugs target the µ opioid receptor (MOR), a heterodimer between the MOR and the δ opioid receptor (DOR) has emerged as another target to develop safer analgesics. Although some heterodimer-preferring agonists have been reported so far, it is still difficult to activate the MOR/DOR heterodimer selectively in the presence of MOR or DOR monomers/homodimers.
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