Publications by authors named "K Asaoka"

Traumatic intracranial cerebral artery dissection (ICAD) in the pediatric population is relatively rare. We report two traumatic ICAD cases in children. Case 1: A 13-year-old boy presented with headache and left hemiparesis after body contact while playing basketball.

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  • * A brain biopsy confirmed the diagnosis of acute disseminated encephalomyelitis (ADEM), specifically its aggressive form called acute hemorrhagic leukoencephalitis (AHLE).
  • * Treatment with corticosteroids resulted in full recovery, emphasizing the need for awareness of AHLE in older patients and the potential for related eye conditions like retinal vasculitis.
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  • Cell therapy using MultiStem, a multipotent progenitor cell product from bone marrow, is being evaluated for its potential to treat ischemic stroke, which involves a lack of blood flow to the brain.
  • The TREASURE trial, a double-blind, placebo-controlled study conducted at 44 centers in Japan, aimed to determine the safety and efficacy of MultiStem when given to patients within 18-36 hours of stroke onset.
  • Key outcomes were measured through various scales at 90 and 365 days post-treatment, assessing safety and overall recovery, with the study involving 206 patients (104 receiving MultiStem and 102 receiving placebo).
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The biogenic amine dopamine (DA) regulates various physiological and behavioral processes in insects through binding with specific receptors. Three types of typical receptors are known to date. Previously, we achieved functional and pharmacological characterization of the three DA receptors in the silkworm Bombyx mori (BmDopR1-3).

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Objective: Recent studies evaluating plaque protrusion at carotid artery stenting (CAS) using optical coherence tomography showed not a few cases of plaque protrusion when using double-layer micromesh stents. We report a case of symptomatic internal carotid artery (ICA) stenosis with at-risk unstable plaques in which CAS was successfully performed using a stent-in-stent technique by the combined use of a closed-cell stent and a dual-layer micromesh stent.

Case Presentation: An 87-year-old Japanese man with dysarthria and right hemiparesis was diagnosed with atheromatous cerebral embolism caused by severe left ICA stenosis on MRI and DSA.

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