Publications by authors named "K Arai"

Objective: This study evaluated the efficacy and safety of NPC-25, zinc histidine hydrate, in patients with hypozincemia. This randomized multicenter active-controlled open-label trial aimed to verify the non-inferiority of NPC-25 to NOBELZIN™, zinc acetate dihydrate.

Methods: Participants whose serum zinc concentrations were <70 μg/dL at two points within 8 weeks before the start of treatment were randomized 1:1 into the NPC-25 (active drug) administration group and the NOBELZIN™ (control drug) administration group, using dynamic allocation.

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Case Summary: A 13-year-old castrated male American Shorthair cat was referred for evaluation following a 3-week history of poor balance and decreased activity. The MRI findings revealed a well-defined left caudal cerebellar mass with a diameter of 1.2 cm, consistent with a meningioma.

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Article Synopsis
  • - Chronic cerebral hypoperfusion (CCH) causes long-term reduced blood flow to the brain, leading to neurodegenerative diseases like Alzheimer's and vascular dementia, with rodent models helping to study its effects.
  • - CCH induces oxidative stress through cellular disruptions, resulting in damage to neurons and worsened cognitive function due to the buildup of reactive oxygen species (ROS).
  • - Edaravone, an antioxidant initially used for ischemic stroke, shows promise in rodent studies for protecting against neuronal damage by reducing oxidative stress in CCH conditions.
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Many older adults who are certified for long-term care services live or stay in long-term care facilities (LTCFs), where they receive medical and nursing care. These individuals often encounter medication-related problems, such as polypharmacy and complex medication regimens, including frequent administration schedules. Although considerable attention has been paid to polypharmacy in the context of optimizing medication use in older adults, little emphasis has been placed on simplifying these regimens.

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