Publications by authors named "K Aouam"
Unlabelled: Introduction-Aim: The iatrogenic risk in the elderly is a real public health problem due to its frequency and seriousness. Our study aimed to analyze the epidemiological, clinical and chronological aspects of adverse drug reactions occurring in elderly subjects and to identify the incriminated drugs.
Methods: We carried out a retrospective study of all the observations of adverse drug reactions in elderly subjects, notified to the Clinical Pharmacology department of Monastir over a period of 17 years (2004 - 2020).
Article Synopsis
- Thiopurine drugs are used to treat conditions like inflammatory bowel disease, and their metabolism is influenced by the enzymes TPMT and ITPA.
- This study focuses on Tunisian patients to assess how genetic factors and other variables affect the pharmacokinetics of thiopurine drugs.
- The research found specific genetic variants and identified gender as a significant factor affecting drug variability, emphasizing the importance of TPMT testing for optimal treatment safety and efficacy.
Introduction: Human cytochrome P450 (CYP), particularly CYP3A4 and CYP3A5 is mainly responsible for the metabolism of several drugs including tacrolimus. Significant interracial/interethnic variation in the expression and function of CYP3A5 and CYP3A4 is caused by Single Nucleotide Polymorphisms (SNPs) of genes encoding these proteins.
Aim: The present study investigated the genetic polymorphisms CYP3A4*1B, CYP3A4*22, and CYP3A5*3 in the Tunisian population.
Article Synopsis
- * Using a nonparametric approach, the model examined how factors like age and kidney function (creatinine clearance) affected drug distribution and clearance.
- * Results showed that the model accurately predicts vancomycin levels, highlighting the need for personalized dosing to ensure optimal effectiveness and safety for patients with varying degrees of renal impairment.