[Effect of furosemide on transperitoneal transport of guanidine derivatives: in vitro studies].

The transperitoneal transport dynamics (removal) of guanidinoacetic acid (GAA) and guanidinosuccinic acid (GSA) has been determined in vitro in the control conditions and after application of furosemide (10(-4) mmol/l) on the mesothelial side of the membrane. GAA peritoneal transfer values, as a rule, were higher than GSA and equaled at mean, in the control series of experiments 0.132 i 0.

[Uremic polyneuropathy in patients treated conservatively (nondialyzed) or treated with dialysis].

Uremic polyneuropathy is a common complication in dialyzed patients (pts). In 37 end stage renal disease (ESRD) pts the electroneurophysiological (ENF) parameters and serum creatinine (Pcr), guanidino compounds (GC) and guanidinosuccinic acid (GSA) levels were studied. There were 21 nondialyzed (ND), 10-hemodialyzed (HD) and 6-intermittently peritoneally dialyzed (IPD) pts.

[Peritoneal blood flow and peritoneal transfer parameters during intermittent peritoneal dialyses performed with administration of sodium nitroprusside or chlorpromazine].

Effective peritoneal capillary blood flow (EPBF) was evaluated by calculation of diffusive mass transport coefficient of CO2 during intermittent peritoneal dialysis performed with intraperitoneal administration of sodium nitroprusside (NP, 5 mg/l of dialysis solution) or chlorpromazine (Cl-Prom, 2.5 mg/l of dialysis solution). Peritoneal transfer rates of substances of different molecular size and charge were simultaneously examined and compared with EPBF.

Peritoneal blood flow and peritoneal transfer parameters during dialysis with administration of drugs.

Effective peritoneal capillary blood flow (EPBF) was evaluated by calculating the diffusive mass transport coefficient of carbon dioxide during intermittent peritoneal dialysis (IPD) performed with the intraperitoneal administration of sodium nitroprusside (NP), chlorpromazine (CP), or isoproterenol (IP) in the doses 5, 2.5, and 0.5 mg/L, respectively.

[Levels of plasma proteins in patients with ene stage renal failure treated with peritoneal dialysis with an addition of furosemide to dialysis fluid].

This study aimed at evaluating an effect of repeated intraperitoneal furosemide administration on plasma proteins in patients with uremia given the drug to increase intermittent peritoneal dialysis efficiency. Patients (n = 6) dialysed for 48-60 hours per week furosemide was added to dialysis fluid in the dose of 1.2-2.