Publications by authors named "K Amano"
Introduction: Acquired haemophilia A (AHA) is characterized by the development of autoantibodies against factor VIII, reducing its activity and potentially resulting in bleeding.
Aim: To assess the characteristics of people with AHA undergoing rehabilitation and/or with low activities of daily living (ADL) scores, thereby characterizing unmet needs in the management of AHA and informing treatment optimization.
Methods: ORIHIME II, the largest epidemiological and treatment survey of AHA in Japan, is a descriptive, retrospective, observational study conducted using health claims data from April 2008 to October 2021.
The treatment of the underlying cause of liver disease may potentially reverse hepatic fibrosis. However, it remains uncertain whether improvement in fibrosis can be observed in decompensated liver cirrhosis (LC). Here, we present a case of autoimmune hepatitis (AIH)-related LC in which histological improvement of fibrosis was achieved despite the presence of decompensated LC.
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- The text discusses the use of transit-time flow measurement (TTFM) during coronary artery bypass grafting (CABG) as a modern and efficient method for evaluating graft flow.* -
- Key measurable parameters such as mean graft flow, pulsatility index, diastolic filling, and systolic reverse flow are assessed to predict the success of CABG grafts, although cut-off values vary based on hemodynamic conditions.* -
- The review highlights the importance of fast Fourier transform (FFT) analysis of TTFM waveforms, suggesting that waveform morphology may provide additional insights into graft quality beyond standard flow measurements.*
Article Synopsis
- JAK inhibitors, used to treat rheumatoid arthritis, can increase the risk of herpes zoster, prompting the need for appropriate vaccination timing with the recombinant zoster vaccine (RZV).
- The STOP HZ study aims to determine whether initiating tofacitinib at the first or second RZV vaccination affects patients' immune response (IgG titers and T cell response) and disease activity.
- This multicenter, randomized study will recruit 60 patients and measure various treatment outcomes, all while conforming to ethical guidelines and requiring informed consent.
Objectives: To describe safety and efficacy of filgotinib 200 or 100 mg (FIL200/FIL100) in Japanese patients with rheumatoid arthritis in a long-term extension (LTE; NCT03025308).
Methods: Patients who completed any of three parent studies (NCT02889796: inadequate response [IR] to methotrexate [MTX]; NCT02873936: IR to biologic disease-modifying antirheumatic drugs; NCT02886728: MTX-naïve) without rescue therapy could enter the LTE; patients taking FIL continued their dosage, and those who received comparators were rerandomised to FIL200 or FIL100. This analysis includes week 156 interim results.