Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice.

The classical psychedelic psilocybin is of interest as a treatment for alcohol use disorder (AUD). This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice administered saline or psilocybin intraperitoneally as a single dose of 0.1, 0.

Long term erectile function results of radical perineal prostatectomy.

Introduction: Although many patients are being treated by radical prostatectomy (RP), there is still insufficient information about the changes in long-term erectile function after RP. Our aim is to examine long term, up to 5 year erectile function status of patients after Radical Perineal Prostatectomy (RPP).

Materials And Methods: One hundred and thirty-two patients, who underwent bilateral nerve-sparing Radical Perineal Prostatectomy (RPP) in between January 2012 and January 2017, with preoperative age≤70, prostate volume<80g, transrectal ultrasound (TRUS) guided biopsy Gleason score (GS)<7, prostate specific antigen (PSA) value<10ng/mL, and cT stage≤2 (N0, M0) were included into this study.

Case Report: Famotidine for Neuropsychiatric Symptoms in COVID-19.

Famotidine is of interest as a possible treatment for COVID-19, with effects on disease-related symptoms and survival reported in observational and retrospective studies, as well as predictions of binding to potential SARS-CoV-2 drug targets. Published studies of famotidine for COVID-19 have focused on acute illness, and none have reported on neuropsychiatric symptoms. This case study reports on an 18-year-old man who sought psychiatric treatment for depression and anxiety, disruptive interpersonal conflicts, and impairments in attention and motivation following mildly symptomatic illness with COVID-19.

One-pot transformation of lignocellulosic biomass into crude bio-oil with metal chlorides via hydrothermal and supercritical ethanol processing.

Grape seeds were deconstructed in both hydrothermal and supercritical ethanol media with a combination of two metal chlorides (TiCl:MgCl) to produce bio-oils. The use of metal chloride additives in supercritical ethanol achieved the highest bio-oil yield of 49.2 wt% (300 °C, 30 min).

LSD Administered as a Single Dose Reduces Alcohol Consumption in C57BL/6J Mice.

There is a substantive clinical literature on classical hallucinogens, most commonly lysergic acid diethylamide (LSD) for the treatment of alcohol use disorder. However, there has been no published research on the effect of LSD on alcohol consumption in animals. This study evaluated the effect of LSD in mice using a two-bottle choice alcohol drinking paradigm.