Publications by authors named "K Alexander Iwen"
Article Synopsis
- Thyroid hormones play a crucial role in regulating body temperature and energy metabolism, with medical conditions like hyperthyroidism and hypothyroidism directly affecting these processes.
- Recent research highlights the roles of specific thyroid hormone receptors, particularly TRα1 and TRβ, in body temperature regulation, although the exact functions and brain areas involved are still unclear.
- Experiments using mutant TRα1 mice and TRβ knockouts showed that TRα1 is vital for maintaining body temperature, with T3 treatment being effective in normalizing temperature in mutant mice, indicating it's crucial for setting the central temperature in the hypothalamus.
Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine to overcome tissue hormone resistance does not elevate their heart rate. Cardiac telemetry in male, TRα1 mutant, mice indicates that such persistent bradycardia is caused by an intrinsic cardiac defect and not due to altered autonomic control.
View Article and Find Full Text PDFBackground: Predicting a multiple gland disease (MGD) in primary hyperparathyroidism (pHPT) remains challenging. This study aimed to evaluate predictive factors for MGD.
Methods: A retrospective chart review was performed of 1211 patients with histologically confirmed parathyroid adenoma or hyperplasia between 2007-2016.
Background: Based on risk stratification, the therapeutic options in papillary microcarcinoma (PTMC) can be active surveillance or surgery. Multifocal tumor occurrence can be decisive in determining the treatment strategy. The objective of this study was to identify risk factors for bilateral tumor occurrence in PTMC to enable individual therapy planning.
View Article and Find Full Text PDFBackground: Primary hyperparathyroidism (pHPT) is well treatable surgically. Sonography (US) and sestamibi scintigraphy (MIBI) are used routinely, but it is unclear how valuable they are in determining Parathyroid glands' different locations. This study aimed to evaluate the prognostic value of US and MIBI in relation to the different localization of parathyroid adenomas in one of the largest study populations analyzed to date.
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